Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy

Oral squamous cell carcinoma (OSCC) is the most frequent type of oral cancer multifactorial origin, characterized by histological and clinical manifestations. To date, there are no specific biomarkers or treatment modalities available to efficiently manage this neoplasia, demanding further research on molecular background OSCC pathology. Elucidation signal transduction pathways associated molecules with differential expression function in expected enhance future development targeted therapies. Among signaling proteins a potential functional role OSCC, High Mobility Group Box 1 (HMGB1) protein has stimulated scientific interest due upregulation, implication progression many types head neck types. HMGB1 nuclear nonhistone an extracellularly secreted cytokine that can interact several implicated pathogenic OSCC. Binding receptors cells such as receptor AGE (RAGE) toll-like (TLR) been shown initiate intercellular cascades promote growth, invasion, metastasis, indicating target for patient prognosis therapeutic approaches. The purpose review explore order reveal targeting options.